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Sixty-five  Conditions Associated with Magnesium Deficiency – In the introduction to the first edition of The Magnesium Miracle, I listed twenty-one conditions that have a direct clinical correlation with magnesium deficiency and respond to magnesium treatment. From more recent magnesium research and clinical experience, I’ve expanded this list to 65 conditions.
What follows is an overview of these conditions, some of which I will develop further in the text.
1. Acid reflux. Spasm of the lower esophageal sphincter at the juncture of the stomach can leave the sphincter open causing acid reflux, GERD or heartburn. Magnesium relieves esophageal spasms.
2. Adrenal fatigue. Adrenal fatigue follows after a time of chronic stress, anxiety, and panic attacks and it seems to be occurring in epidemic proportions. Adrenaline, noradrenaline, and cortisol (elevated in chronic stress) deplete magnesium. Stress causes excess elimination of magnesium through the urine, further compounding magnesium deficiency. Stress is such an overworked word, but we all suffer physical, emotional, and mental stress every day, and every bit of it drains magnesium.
3. Alzheimer’s disease. Magnesium blocks the neuroinflammation caused by the inappropriate deposition of calcium and other heavy metals in brain cells. Magnesium is at work even before the inflammation appears, guarding cell ion channels and not allowing heavy metals to enter. Picometer, stabilized ionic magnesium (ReMag) easily enters cells and can help eliminate heavy metals and solubilize calcium.
4. Angina. The pain of angina is caused by severe muscle spasms in heart muscles, which are caused by magnesium deficiency. The heart ventricles have the highest levels of magnesium in the whole body; this is why magnesium is so important for the pumping function of the heart.
5. Anxiety and panic attacks. When the adrenals are no longer protected by sufficient magnesium, the fight-or-flight hormones, adrenaline and noradrenaline become more easily triggered. When they surge erratically, they cause a rapid pulse, high blood pressure, and heart palpitations. The more magnesium-deficient you are, the more exaggerated is the adrenaline response. Magnesium calms the nervous system, relaxes muscle tension, and lowers the pulse rate, helping to reduce anxiety and panic attacks.
6. Arthritis. Magnesium can help dissolve calcium that builds up in joint spaces. It also can treat the pain and inflammation of arthritis as a safe substitute for pain medication.
7. Asthma. Histamine production and bronchial spasms (in the smooth muscles of the bronchial tract) both increase simply as a result of magnesium deficiency.
8. Atherosclerosis with calcium deposits. Magnesium is necessary to help dissolve calcium and keep it soluble in the bloodstream. Magnesium, along with vitamin K2, helps direct calcium to the bones where it belongs.
9. Blood clots. Magnesium does not act like a blood-thinning drug. Instead, it prevents the calcium build up that triggers clots. Magnesium naturally balances the blood clotting factors in the blood.
10. Bowel disease. Magnesium deficiency slows down bowel peristalsis, causing constipation, which can lead to toxicity as well as symptoms of colitis, IBS, diverticulitis, and Crohn’s disease.
11. Brain dysfunction. You can obtain a free copy of the 355-page book, Magnesium in the Central Nervous System (2011) online and read an extensive overview of the beneficial effects of magnesium on the brain. (See Chapter 5 for a list of chapters.)[i]
12. Bruxism or teeth grinding. Up to 80% of cases of bruxism occur during sleep and your dentist may be the first to notice that your teeth are being gradually worn down. Bruxism is related to clenching of the jaw muscles during the day and is usually associated with stress or anxiety. Any muscle tension can be the result of magnesium deficiency.
13. Cholesterol elevation. When I was in medical school in the mid-1970s, normal cholesterol levels were around 245 mg/dL. In the first edition of The Magnesium Miracle I reported allopathic medicine’s “normal” value of cholesterol at 180–220 mg/dL. Now, doctors are advising that cholesterol should be below 200 mg/dL (5.2 mmol/L) to be considered normal. What doctors don’t seem to know is that magnesium, bound to ATP Mg(2+)-ATP, is the controlling factor for the rate-limiting enzyme in the cholesterol biosynthesis sequence that is targeted by the statin pharmaceutical drugs.[ii] Thus, magnesium is responsible for naturally slowing down HMG-CoA reductase activity when cholesterol is present in sufficient quantities. To repeat, this is the same enzyme that statin drugs target for destruction, while creating magnesium deficiency.
14. Chronic fatigue syndrome. I write about CFS in Chapter 15. It is remarkable how much magnesium, especially ReMag, can help people get their energy back and get back on track by taking therapeutic magnesium. We still don’t know what causes CFS but, in my discussion about the interaction between calcium and magnesium, I wonder if calcium excess and magnesium deficiency could be the underlying cause of mitochondrial dysfunction that many natural medicine practitioners say can trigger chronic fatigue syndrome and other chronic diseases
15. Cystitis. Magnesium deficiency causes bladder spasms, which can cause urinary frequency often misinterpreted as a bladder infection. Magnesium deficiency can also allow calcium to build up in the lining of the bladder and urethra causing irritation that mimics cystitis. We’ve had reports from elderly women who have thrown away their adult diapers because, apparently, ReMag dissolves bladder tissue calcification and eliminates incontinence.
16. Depression. Serotonin, a neurotransmitter that elevates mood, depends on magnesium for its production and function whether it’s made in the brain or in the intestines. Dopamine, a neurotransmitter that helps control the brain’s reward and pleasure centers utilizes magnesium in several steps in its biochemical pathway. A magnesium-deficient brain is also more susceptible to allergens and foreign substances, which in some instances can cause symptoms similar to mental illness.
17. Detoxification. Magnesium is crucial for the removal of toxic substances and heavy metals such as mercury, aluminum, and lead from the cells. Magnesium is a cofactor in both the production of glutathione and the function of the P450 detoxification systems in the liver.
18. Diabetes. Magnesium is necessary to make and secrete insulin; it facilitates carbohydrate metabolism; and allows insulin to transfer glucose into cells. Otherwise, glucose and insulin build up in the blood causing various types of tissue damage. Tyrosine kinase, an enzyme that allows glucose entry into the cell (along with insulin) is magnesium-dependent. Seven of the ten enzymes needed to metabolize glucose in the process called glycolysis are also magnesium-dependent. This cycle functions in the cytosol – the watery component of the cytoplasm.
19. Fatigue. Magnesium-deficient patients commonly experience fatigue because dozens of enzyme systems are underfunctioning. The most important factor in energy production is ATP, which must be bound to a magnesium ion in order to be biologically active. ATP is produced in the Krebs cycle, which requires magnesium in 6 of its 8 steps. The Krebs cycle begins by using pyruvate from the glycolysis cycle and functions exclusively in the mitochondria.
20. Headaches. Muscle tension and spasm in neck and head muscles can be alleviated with magnesium therapy, which can be applied locally and taken orally.
21. Heart disease. The heart, specifically the left ventricle, has the highest amount of magnesium in the whole body. Magnesium deficiency is common in people with heart disease, and taking magnesium can reduce that risk. IV magnesium can prevent myocardial infarction damage and cardiac arrhythmia if given at the onset of a heart attack. Most drugs used in treating heart disease drain magnesium from the body.
22. Hypertension. With insufficient magnesium and too much calcium, the smooth muscles lining blood vessels can go into spasm and cause high blood pressure. If cholesterol is elevated, which can also be due to magnesium deficiency, cholesterol can bind to calcium causing atherosclerosis in the blood vessels, worsening high blood pressure.
23. Hypoglycemia. Magnesium balances the release of insulin so that inappropriately large amounts aren’t released, which would cause the blood sugar to drop suddenly, resulting in symptoms of low blood sugar.
24. Indigestion. The gastric proton pump that acidifies the contents of the stomach for proper digestion is dependent on magnesium.
25. Inflammation. Most drug companies are now embracing inflammation and not cholesterol as the cause of heart disease. They don’t know what causes inflammation, but that doesn’t stop them from producing drugs to suppress it. They don’t acknowledge that calcium is extremely proinflammatory and magnesium is very anti-inflammatory. The entire inflammatory cascade (substance P, interleukins, tumor necrosis factor, chemokines, and cytokines) escalates when magnesium is deficient.[iii] The bottom line is that inflammation is triggered by magnesium deficiency and relative calcium excess.
26. Insomnia. Magnesium relieves the muscle tension that can prevent restful sleep. Also, sleep-regulating melatonin pathway production is disturbed without sufficient magnesium. Magnesium is so effective as a sleep aid that if someone is taking magnesium and their sleep is not improved, I say, “Take more magnesium.” You may have to take ReMag to get the therapeutic effect without the laxative effect.
27. Irritable bowel syndrome. In my book IBS for Dummies, I describe the importance of magnesium in the treatment of pain and spasm in IBS.[iv]
28. Kidney disease. Magnesium deficiency contributes to atherosclerotic kidney failure because calcium builds up in the kidney arteries. Magnesium deficiency leads to abnormal lipid levels and worsening blood sugar control in kidney transplant patients. It’s important for kidney patients to receive picometer, stabilized ionic magnesium (ReMag) that is absorbed directly into cells and therefore does not build up in the blood to cause electrolyte imbalance and rhythm disturbances.
29. Kidney stones. See Chapter 11 for evidence of magnesium’s ability to prevent and treat kidney stones, especially when combined with its partner, vitamin B6.
30. Migraine. Deficiency of serotonin can result in migraine headaches and depression. Serotonin depends on magnesium for proper balance. Also, tiny blood clots can block capillaries in the brain, leading to migraines. Magnesium prevents calcium from causing excessive blood clotting. It is well known that IV and oral magnesium can treat and prevent migraine headaches.
31. Musculoskeletal conditions. Insufficient magnesium and the relative excess of calcium will cause sustained muscle contraction in any muscle group in the body. The following musculoskeletal conditions are amenable to magnesium therapy:
a. Muscle cramps
d. GI spasms (chronic pain from undiagnosed spasms can lead to inappropriate exploratory surgery)
d. Tension headaches
e. Muscle spasms or muscle contractions in any muscle of the body
f. Chronic neck and back pain
g. Jaw tension
32. Nerve problems – Neuralgia, Neuritis, Neuropathy. Insufficient magnesium and the relative excess of calcium will cause sustained nerve excitation in any nerve cells in the body. Magnesium alleviates the following nerve disturbances that can occur:
a. Burning pain
b. Muscle weakness
e. Pins-and-needles sensations
f. Seizures and convulsions
g. Skin sensitivity
33. Obstetrical and gynecological problems. Magnesium helps prevent and treat the following:
a. Premenstrual syndrome
b. Dysmenorrhea (cramping pain during menses)
c. Female infertility (by relieving fallopian tube spasm)
d. Premature contractions (which can be triggered by magnesium deficiency muscle spasms)
e. Preeclampsia and eclampsia in pregnancy (treating fluid retention, high blood pressure, and seizures)
f. Cerebral palsy
g. Sudden infant death syndrome (SIDS)
h. Male infertility (magnesium and zinc are present in significant quantities in healthy semen)
34. Osteoporosis. Low magnesium in the presence of elevated calcium, with or without vitamin D, triggers a cascade of events leading to bone loss.
35. Parkinson’s disease. Dopamine deficiency results in Parkinson’s disease and magnesium is a required cofactor in the production of dopamine. Magnesium blocks the neuroinflammation caused by calcium deposits in the brain.
36. Raynaud’s syndrome. Magnesium helps relax the spastic blood vessels that cause pain and numbness of the fingers.
37. Sports injuries. Pain, inflammation, muscle spasm, muscle tension, and scarring can all be treated with magnesium.
38. Sports recovery. Magnesium reduces lactic acid buildup and replaces magnesium sweat loss that can result in post-exercise pain.
39. Tempromandibular joint syndrome (TMJ). This hinge joint connects the jaw bone to the cheek bone. The joint can become irritated and inflamed due to arthritis, gum chewing, injury to the teeth or jaw, misalignment of the teeth or jaw, poor posture, stress, and teeth grinding. Most of these factors are aggravated by magnesium deficiency.
40. Tongue biting. In a magnesium-deficient person, while eating, the muscles of the tongue and the muscles lining the inside of the mouth can go into spasm causing the teeth to suddenly and inadvertently clamp down on the tongue or the lining of the inside of the mouth.
41. Tooth decay. Magnesium deficiency causes an unhealthy balance of phosphorus and calcium in saliva, which damages the teeth.
[ii] Rosanoff A, Seelig MS, “Comparison of mechanism and functional effects of magnesium and statin pharmaceuticals.” J Am Coll Nutr, vol. 23, no. 5, pp. 501S–505S, 2004.
[iii] Weglicki WB, Phillips TM, “Pathobiology of magnesium deficiency: a cytokine/neurogenic inflammation hypothesis.” Am J Physiol, vol. 263, no. 3, part 2, R734–37, 1992.
[iv] Dean CFA, Wheeler LC. IBS for Dummies. Wiley Nov 2005.